AZD-8330
AZD-8330 is an inhibitor of MEK1/2 that exhibits anticancer chemotherapeutic activity. AZD-8330 is currently in clinical trials for the treatment of advanced stage cancers.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18842808
| Cas No. |
869357-68-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C16H17FlN3O4 |
| Formula Wt. |
461.23 |
| IUPAC Name |
2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxopyridine-3-carboxamide |
| Synonym |
ARRY-704, ARRY-424704 |
| Appearance |
White Powder |
Cohen RB, Aamdal S, Nyakas M, et al. A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies. Eur J Cancer. 2013 May;49(7):1521-9. PMID: 23433846.
Akinleye A, Furqan M, Mukhi N, et al. MEK and the inhibitors: from bench to bedside. J Hematol Oncol. 2013 Apr 12;6:27. PMID: 23587417.
