5-Fluorocytosine
5-Fluorocytosine, or Flucytosine, is a synthetic fluorinated pyrimidine analog that is used as an antifungal agent. In the presence of the enzyme cytosine deaminase it is converted to 5-fluorouracil, an antimetabolite that is an inhibitor of thymidylate synthase.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18834415
| Cas No. |
2022-85-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C4H4FN3O |
| Formula Wt. |
129.09 |
| Chemical Name |
6-amino-5-fluoro-2(1H)-pyrimidinone |
| IUPAC Name |
4-Amino-5-fluoro-2(1H)-pyrimidinone |
| Synonym |
Flucytosine, Ancobon, Ancotil, 5-FC, NSC 103805, Ro 2-9915 |
| Solubility |
Soluble in water (1.5 g/100 mL or 0.089 M). |
Huang TT, Parab S, Burnett R, et al. Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model. Hum Gene Ther. 2015 Feb; 26(2):82-93. PMID: 25419577.
Davoudi N, Khamesipour A, Mahboudi F, McMaster WR. A dual drug sensitive L. major induces protection without lesion in C57BL/6 mice. PLoS Negl Trop Dis. 2014 May 29; 8(5):e2785. PMID: 24873970.
O’Connor L, Livermore J, Sharp AD, et al. Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients. J Infect Dis. 2013 Jul 15; 208(2):351-361. PMID: 23599314.
