5,6-Dehydrokawain
5,6-Dehydrokawain is a kavalactone originally found in Piper methysticum (kava plant) and Alpinia that exhibits neuroprotective and antithrombotic activities. 5,6-Dehydrokawain inhibits aggregation and ATP release of platelets as well as formation of thromboxane B2 (TxB2). Additionally, this compound prevents H2O2-induced toxicity, decreasing release of lactate dehydrogenase, activation of caspase 3, and oxidative stress in neurons.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18834494
| Cas No. |
1952-41-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C14H12O3 |
| Formula Wt. |
228.25 |
| IUPAC Name |
4-methoxy-6-[(E)-2-phenylethenyl]pyran-2-one |
| Melting Point |
138-140°C |
| Appearance |
White/ Off White Powder |
Rao YK, Shih HN, Lee YC, et al. Purification of kavalactones from Alpinia zerumbet and their protective actions against hydrogen peroxide-induced cytotoxicity in PC12 cells. J Biosci Bioeng. 2014 Jun 11. [Epub ahead of print]. PMID: 24929995.
Teng CM, Hsu SY, Lin CH, et al. Antiplatelet action of dehydrokawain derivatives isolated from Alpinia speciosa rhizoma. Chin J Physiol. 1990;33(1):41-8. PMID: 2376215.
