4-Bromoflavone
4-Bromoflavone displays antioxidative and chemopreventive activities. 4-Bromoflavone activates Nrf2-Keap1-ARE complex signaling and also induces quinone reductase and other phase II enzymes. Additionally, this compound prevents the development of mammary tumors, increasing tumor latency in vivo.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18833856
| Cas No. |
1218-80-0 |
|---|---|
| Purity |
≥98% |
| Formula |
C15H9BrO2 |
| Formula Wt. |
301.13 |
| IUPAC Name |
6-bromo-2-phenylchromen-4-one |
| Synonym |
6-Bromo-2-phenylbenzopyran; 6-Bromo-2-pheynyl- 4H-1-benzopyran-4-one; 6-Bromoflavone |
| Melting Point |
176-178°C (lit.) |
| Appearance |
Off-White crystalline powder |
Lee JS, Surh YJ. Nrf2 as a novel molecular target for chemoprevention. Cancer Lett. 2005 Jun 28;224(2):171-84. PMID: 15914268.
Mehta RG, Pezzuto JM. Discovery of cancer preventive agents from natural products: from plants to prevention. Curr Oncol Rep. 2002 Nov;4(6):478-86. PMID: 12354359.
Song LL, Kosmeder JW 2nd, Lee SK, et al. Cancer chemopreventive activity mediated by 4-bromoflavone, a potent inducer of phase II detoxification enzymes. Cancer Res. 1999 Feb 1;59(3):578-85. PMID: 9973203.
