1,4-DPCA
1,4-DPCA is an inhibitor of prolyl hydroxylase that stabilizes expression of HIF-1α and exhibits anticancer and pro-angiogenic activities. In breast cancer cells, 1,4-DPCA inhibits cell proliferation and decreases deposition of collagens I and IV. This compound also limits growth of connective tissue on biomaterials and implanted medical devices.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18831617
| Cas No. |
331830-20-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C13H8N2O3 |
| Formula Wt. |
240.22 |
| Chemical Name |
4,4alpha-dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid |
| IUPAC Name |
4-Hydroxy-1,10-phenanthroline-3-carboxylic acid |
| Synonym |
1,4-Dihydrophenonthrolin-4-one-3-carboxylic acid, 3-Acetyl-1H-[1,10]phenanthrolin-4-one |
| Appearance |
Tan Powder |
product targets : G-quadruplex inhibitors
Zhang Y, Strehin I, Bedelbaeva K, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7(290):290ra92. PMID: 26041709.
Xiong G, Deng L, Zhu J, et al. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2;14:1. PMID: 24383403.
Love RJ, Jones KS. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101(12):3599-606. PMID: 23766241.
